The Advanced IT Core represents a collaboration between the IU School of Medicine (IUSM) and the Research Technologies (RT) division of University Information Technology Services (UITS), the central IT services organization at Indiana University. Research Technologies has traditionally provided high-end computing, storage, and visualization resources to university researchers at large.

The AITC has been created to be a dedicated resource for the Health Care and related sciences researchers at IU. It reflects the university's ongoing commitment to support Indiana's various life sciences initiatives. Originally funded through the Indiana Genomics (INGEN) initiative, the AITC now aims to serve Health Care and related sciences researchers at large. In particular, it provides access to Indiana University supercomputing, information management, and visualization resources.

In early 2009, the AITC completed its efforts to make Research Technologies resources aligned with HIPAA to enable researchers to analyze and store Electronic Protected Health Information (ePHI) on RT systems.